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Periodic Table

Publications

Pete is a co-inventor on over 20 patents and co-author of over 20 peer-reviewed scientific publications. Below is a list of selected publications:

Physical and pharmacokinetic characterization of Soluvec, a novel, solvent-free aqueous ivermectin formulation

Ther. Deliv. 2023, 14, 391-399.

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Phytocannabinoid Pharmacology: Medicinal Properties of Cannabis sativa Constituents Aside from the “Big Two” 

J. Nat. Prod. 2021, 84, 142−16.

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Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial

Br. J. Cancer 2019, 121, 318-324.​

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Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy

Bioorg. Med. Chem. Lett. 2016, 26, 4625-4630. 

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Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent

ACS Med. Chem. Lett. 2016, 7, 671-675.​

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The Discovery of Polo-Like Kinase 4 Inhibitors: Design and Optimization of Spiro[cyclopropane-1,3′[3H]indol]-2′(1′H)-ones as Orally Bioavailable Antitumor Agents

J. Med. Chem. 2015, 58, 130-146 

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The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

J. Med. Chem. 2015, 58, 147-169.

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Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI).

Bioorg. Med. Chem. Lett. 2009, 19, 5355-5358.

Investigation of Bioisosteric Effects on the Interaction of Substrates/Inhibitors with the Methionyl-tRNA Synthetase from Escherichia coli

Medicinal Chemistry 2005, 1, 227-237. 

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Synthesis and Structure-Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor

J. Med. Chem. 2004, 47, 3, 744–755.​

Methionine In and Out of Proteins: Targets for Drug Design

Curr. Med. Chem. 2002, 9, 1867-1892 ​

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Oxidative Deprotection of Diphenylmethylamines

Org. Lett. 1999, 1, 1395-1397.

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Insights into the Mechanism of E. coli Methionine Aminopeptidase from the Structural Analysis of Reaction Products and Phosphorus-based Transition State Analogs

Biochemistry 1999, 38, 14810-14819.​

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